Sex Hormones and Peripheral White Blood Cell Subsets in Systemic Lupus Erythematosus Patients
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Abstract:
Background: Systemic Lupus Eyrythematosus (SLE) is an autoimmune disease charac-terized by antibodies to nuclear antigens, particularly anti-dsDNA. Imbalance between production and destruction of immune cells causes cytopenia. Sex hormones have im-munomodulatory effects; estrogen increases the production of autoantibodies in SLE prone NZB/NZW mice. Objective: To investigate the relationship between sex hor-mones, anti-dsDNA, and lymphocyte subsets in Iranian patients with SLE. Methods: 38 SLE patients (28 females and 10 males) meeting 4 of 11 ACR revised criteria for SLE classification, and 20 age and sex matched healthy individuals (10 females and 10 males) participated in this study. Lymphocyte subsets were analyzed using flow cy-tometric analysis. Serum anti-dsDNA levels and sex hormones concentrations were de-termined using commercial ELISA and RIA kits, respectively. Results: The absolute count of white blood cells, lymphocytes, T lymphocytes (CD3+), T helper cells (CD3+CD4+), B cells (CD19+) and Nk cells (CD3- CD16+CD56+) in SLE patients di-minished significantly in comparison to control group (p
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Journal title
volume 4 issue 2
pages 110- 115
publication date 2007-06-01
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